Tuberous Sclerosis Complex (TSC)

Addressing a Lifelong Genetic Cause of Epilepsy and Calcification

TSC is a multisystem genetic disorder caused by mutations in the TSC1 or TSC2 genes, leading to dysregulated cell growth and the formation of benign tumors (“tubers”) throughout the body and brain.

These tubers often calcify with age, disrupting neuronal signaling and resulting in seizures, autism spectrum symptoms, and developmental delays. Over 80% of individuals with TSC experience epilepsy that can become drug-resistant.

By chelating excess calcium and improving tissue mineral balance, ZY-001 may offer a non-surgical, disease-modifying approach designed to complement current mTOR-based therapies and potentially improve both seizure control and neurodevelopmental outcomes.